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Long tail fibers consist of a phage-proximal and a phage-distal rod, each around 80 nm long and attached to each other at a slight angle. Advances in deep learning–based protein structure prediction, such as AlphaFold2- multimer (AF2M) and ESMFold, provide opportunities for. Tail fibers and the base plate are essential components that facilitate the phage's interaction with its bacterial host. They identify and attach to host bacterial cell surface receptors and are crucial for infection progression. The collar and whiskers are environment-sensing devices, regulating the retraction of the long tail fibers under unfavorable conditions, thus preventing infection.
Abstract Bacteriophage T4 initially recognizes its host cells using its long tail fibers. Long tail fibers consist of a phage-proximal and a phage-distal rod, each around 80 nm long and attached to each
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Bacteriophage T4 initially recognizes its host cells using its long tail fibers. Long tail fibers consist of a phage-proximal and a phage-distal rod, each around 80 nm
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Base plate: is the hexagonal plate with tail fibres, usually 6 in number and used for attachment to the host cell wall during infection. Tail fibres can recognize specific
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The crystal structure of gene product 11 (gp11), a protein that connects the short tail fibers to the baseplate, has been determined to 2.0 Å resolution using multiple wavelength
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The crystal structure of a complex between the tail fibre and tail fibre assembly (Tfa) protein of Escherichia coli phage Mu reveals the mechanisms by which Tfa regulates fibre assembly
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For the purposes of this study, no notable diferences were phages encoded nine annotated tail fiber proteins; however, we only found and reconstruct the density of three fibers in the
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It is shown that adsorbability of T4 is regularly correlated with the extended state of the tail fibers, suggesting that in T4 fiber extension is a necessary condition for adsorption. Furthermore the
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Bacteriophage lambda is an excellent model system to study the tail architecture of bacteriophages. Wang et al. present the cryo-EM structures of the components of the bacteriophage
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The ability to examine individual interactions between a singular set of a phage''s adsorptive machinery (i.e., long tail fibers, short tail fibers, tail spikes,
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P1 also has an icosahedral capsid, a tail with a contractile sheath, a base plate, and tail fibers. l contains a linear double-stranded DNA genome of 48.5kb, a capsid, and a tail (Fig. 7.1b). The finished capsid
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In bacteriophage T4, the final step in the assembly is the attachment of the long tail fibers to the tail. However, in some other systems, such as e.g., the R-type pyocin, the tail fiber is required for
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Siphoviridae, Demerecviridae, and Drexlerviridae have a long, flexible, noncontractile tail, and Myoviridae, Ackermannviridae, Chaseviridae, and Herelleviridae have a long, rigid, and
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The T4 virion has a 1150 Å-long and 850 Å-wide prolate head encapsidating the genome, and a 1200 Å-long contractile tail (Fig 1) .
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We report here the three-dimensional structure of the baseplate–tail tube complex determined to a resolution of 12 Å by cryoelectron microscopy. The
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During contraction, the tail tube extends beneath the baseplate by about one-half of its total length and rotates by 345°, allowing it to cross the host''s periplasmic space.
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Here we report the X-ray structure of the gp15 hexamer and describe its interactions with the T4 neck and tail proteins. We also present a cryo-EM reconstruction of
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Two types of fibers, six 145 nm long tail fibers (LTFs) and six 40 nm short tail fibers (STFs), are attached to the baseplate (Figure 1A) [50,51]. The two sets of tail fibers confer to T4 phage one of the most
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A bacteriophage structure is made of components including a head or capsid, tail, tail fibers, base plate, and genetic material. The diagram of
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Background: The T4 bacteriophage consists of a head, filled with double-stranded DNA, and a complex contractile tail required for the ejection of
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The ability to examine individual interactions between a singular set of a phage''s adsorptive machinery (i.e., long tail fibers, short tail fibers, tail spikes, etc.) and
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Tail fibers are thin, filamentous structures protruding from the bacteriophage baseplate or tail. They identify and attach to host bacterial cell
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Tail fibers and the base plate are essential components that facilitate the phage''s interaction with its bacterial host. Tail fibers are elongated, flexible rods that are
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Depending on the morphology of their tail, phages are classified as Siphoviridae (long flexible tail), Myoviridae (long contractile tail) and Podoviridiae (short tail). The assembly pathway of
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The tail of bacteriophage T4 undergoes large structural changes upon infection while delivering the phage genome into the host cell. The baseplate is located at the distal end of the
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The tail, which is connected to the head after DNA packaging, has a contractile sheath and a baseplate to which are attached the long and short tail
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Bacteriophage T4 initially recognizes its host cells using its long tail fibers. Long tail fibers consist of a phage-proximal and a phage-distal rod, each
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